Adenosine 3',5'-bisphosphate
Encyclopedia
Adenosine 3',5'-bisphosphate is a form of an adenosine nucleotide
with two phosphate groups attached to different carbons in the ribose
ring. This is distinct from adenosine diphosphate
, where the two phosphate groups are attached in a chain to the 5' carbon atom in the ring.
Adenosine 3',5'-bisphosphate is produced as a product of sulfotransferase
enzymes from the donation of a sulfate group from the coenzyme 3'-phosphoadenosine-5'-phosphosulfate
. This product is then hydrolysed by 3'(2'),5'-bisphosphate nucleotidase
to give adenosine monophosphate
, which can then be recycled into adenosine triphosphate
.
Nucleotide
Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...
with two phosphate groups attached to different carbons in the ribose
Ribose
Ribose is an organic compound with the formula C5H10O5; specifically, a monosaccharide with linear form H––4–H, which has all the hydroxyl groups on the same side in the Fischer projection....
ring. This is distinct from adenosine diphosphate
Adenosine diphosphate
Adenosine diphosphate, abbreviated ADP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside adenosine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine....
, where the two phosphate groups are attached in a chain to the 5' carbon atom in the ring.
Adenosine 3',5'-bisphosphate is produced as a product of sulfotransferase
Sulfotransferase
Sulfotransferases are transferase enzymes that catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The most common sulfate donor is 3'-phosphoadenosine-5'-phosphosulfate...
enzymes from the donation of a sulfate group from the coenzyme 3'-phosphoadenosine-5'-phosphosulfate
3'-Phosphoadenosine-5'-phosphosulfate
3'-Phosphoadenosine-5'-phosphosulfate is a derivative of adenosine monophosphate that is phosphorylated at the 3' position and has a sulfate group attached to the 5' phosphate. This anion, abbreviated PAPS, serves as a coenzyme in sulfotransferase reactions...
. This product is then hydrolysed by 3'(2'),5'-bisphosphate nucleotidase
3'(2'),5'-bisphosphate nucleotidase
In enzymology, a 3',5'-bisphosphate nucleotidase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are adenosine 3',5'-bisphosphate and H2O, whereas its two products are adenosine 5'-phosphate and phosphate....
to give adenosine monophosphate
Adenosine monophosphate
Adenosine monophosphate , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine...
, which can then be recycled into adenosine triphosphate
Adenosine triphosphate
Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
.