Acylation stimulating protein
Encyclopedia
Complement 3 through its interaction with factors B and D (adipsine) generates C3a
. In human body, C3a
is rapidily cleaved by :carboxypeptidase B or carbxyopeptidase N that remove the carboxyl-terminal :arginine to generate C3adesArg. Thus, most of plasmatic C3a
is present in C3adesArg form. C3adesArg is more commonly named ASP or acylation-stimulating-protein due to its marked stimulating action on :triacylglycerol synthesis in human :adipocytes and skin fibroblasts. ASP is also known for its augmentation of :glucose transport and inhibiting action on hormone-sensitive lipase. Because of these actions, it is linked to the pathogenesis of :obesity. ASP has also been demonstrated to be present at increased levels in patients with obesity, type II diabetes melitus and coronary artery disease.
ASP ligate a specific receptor named :C5L2 which is coupled with a :G-protein.
C3a (complement)
C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b. It stimulates mast cell degranulation, thus triggering an immune response.C3a plays an important role in chemotaxis, though not as important a role as C5a....
. In human body, C3a
C3a (complement)
C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b. It stimulates mast cell degranulation, thus triggering an immune response.C3a plays an important role in chemotaxis, though not as important a role as C5a....
is rapidily cleaved by :carboxypeptidase B or carbxyopeptidase N that remove the carboxyl-terminal :arginine to generate C3adesArg. Thus, most of plasmatic C3a
C3a (complement)
C3a is a one of the proteins formed by the cleavage of complement component 3; the other is C3b. It stimulates mast cell degranulation, thus triggering an immune response.C3a plays an important role in chemotaxis, though not as important a role as C5a....
is present in C3adesArg form. C3adesArg is more commonly named ASP or acylation-stimulating-protein due to its marked stimulating action on :triacylglycerol synthesis in human :adipocytes and skin fibroblasts. ASP is also known for its augmentation of :glucose transport and inhibiting action on hormone-sensitive lipase. Because of these actions, it is linked to the pathogenesis of :obesity. ASP has also been demonstrated to be present at increased levels in patients with obesity, type II diabetes melitus and coronary artery disease.
ASP ligate a specific receptor named :C5L2 which is coupled with a :G-protein.