Acid-sensing ion channel
Encyclopedia
Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive cationic channels activated by extracellular protons. ASIC proteins are a subfamily of the ENaC
/Deg superfamily of proteins. To date six proteins of the ASIC family have been identified that arise from four genes, ASIC1
, ASIC2
, ASIC3
, and ASIC4
. ASIC1a, 1b and 2a, 2b are splice variants. ASICs are trimeric proteins and can be made up of different combinations of subunits, they can be found throughout both the central
and peripheral nervous system
. The crystal structure of chicken ASIC1a was solved in 2007.
Acid-sensing ion channels are potential drug targets for treating a wide variety of conditions linked to both the CNS and PNS.
ENAC
ENAC may refer to: - a French civil aeronautics academy* Epithelial sodium channel * Italian Civil Aviation Authority...
/Deg superfamily of proteins. To date six proteins of the ASIC family have been identified that arise from four genes, ASIC1
ACCN2
Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.- Function :This gene encodes a member of the degenerin/epithelial sodium channel superfamily...
, ASIC2
ACCN1
Amiloride-sensitive cation channel 1, neuronal is a protein that in humans is encoded by the ACCN1 gene.- Function :This gene encodes a member of the degenerin/epithelial sodium channel superfamily...
, ASIC3
ACCN3
Amiloride-sensitive cation channel 3 is a protein that in humans is encoded by the ACCN3 gene.- Function :This gene encodes a member of the degenerin/epithelial sodium channel superfamily...
, and ASIC4
ACCN4
Amiloride-sensitive cation channel 4 also known as amiloride-sensitive cation channel 4, neuronal or amiloride-sensitive cation channel 4, pituitary or acid-sensing ion channel 4 is a membrane proteinthat in humans is encoded by the ACCN4 gene...
. ASIC1a, 1b and 2a, 2b are splice variants. ASICs are trimeric proteins and can be made up of different combinations of subunits, they can be found throughout both the central
Central nervous system
The central nervous system is the part of the nervous system that integrates the information that it receives from, and coordinates the activity of, all parts of the bodies of bilaterian animals—that is, all multicellular animals except sponges and radially symmetric animals such as jellyfish...
and peripheral nervous system
Peripheral nervous system
The peripheral nervous system consists of the nerves and ganglia outside of the brain and spinal cord. The main function of the PNS is to connect the central nervous system to the limbs and organs. Unlike the CNS, the PNS is not protected by the bone of spine and skull, or by the blood–brain...
. The crystal structure of chicken ASIC1a was solved in 2007.
Acid-sensing ion channels are potential drug targets for treating a wide variety of conditions linked to both the CNS and PNS.