Acetoxyacetylaminofluorene
Encyclopedia
Acetoxyacetylaminofluorene is a derivative of 2-acetylaminofluorene
used as a biochemical tool in the study of carcinogenesis
. It forms adducts with DNA by reacting with guanine
at its C-8 position.; This results in breaks in one strand of the DNA.
2-Acetylaminofluorene
2-Acetylaminofluorene is a carcinogenic and mutagenic derivative of fluorene. It is used as a biochemical tool in the study of carcinogenesis. It induces tumors in a number of species in the liver, bladder and kidney.The metabolism of this compound in the body by means of biotransformation...
used as a biochemical tool in the study of carcinogenesis
Carcinogenesis
Carcinogenesis or oncogenesis is literally the creation of cancer. It is a process by which normal cells are transformed into cancer cells...
. It forms adducts with DNA by reacting with guanine
Guanine
Guanine is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine . In DNA, guanine is paired with cytosine. With the formula C5H5N5O, guanine is a derivative of purine, consisting of a fused pyrimidine-imidazole ring system with...
at its C-8 position.; This results in breaks in one strand of the DNA.