APEX1
Encyclopedia
DNA- lyase is an enzyme
that in humans is encoded by the APEX1 gene
.
with MUTYH
, Flap structure-specific endonuclease 1
and XRCC1
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the APEX1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
APEX1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with MUTYH
MUTYH
MUTYH is a human gene encoding a DNA glycosylase, MUTYH glycosylase, involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA...
, Flap structure-specific endonuclease 1
Flap structure-specific endonuclease 1
Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.-Interactions:Flap structure-specific endonuclease 1 has been shown to interact with Cyclin-dependent kinase 2, EP300, Werner syndrome ATP-dependent helicase, Heterogeneous nuclear ribonucleoprotein A1, Cyclin A2, PCNA,...
and XRCC1
XRCC1
XRCC1 is a DNA repair protein.It complexes with DNA ligase III.-Interactions:XRCC1 has been shown to interact with PARP2, DNA polymerase beta, Aprataxin, Oxoguanine glycosylase, PCNA, APEX1, PNKP and PARP1.-Further reading:-External links:...
.