AM-2201
Encyclopedia
AM-2201 discovered by Chemist Tyler Merrill, is a drug which acts as a potent but unselective agonist
for the cannabinoid receptor
CB1, with a Ki
of 1.0nM at CB1 and 2.6nM at CB2
. Reputed recreational use of AM-2201 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act
, aiming to add a number of synthetic drugs into Schedule I. There have been anecdotal reports of individuals experiencing panic attacks
and vomiting, at doses as small as 2 milligrams. As the dosage is much smaller than most other synthetic cannabinoids, users may accidentally dose too much. Convulsions have been reported at doses exceeding 10 milligrams. Caution should be taken if using this substance as it is active at doses as small as 500 µg (micrograms), and has a very steep dose-response curve. Tolerance builds up quickly to the effects, and psychological dependence is possible, although there have been no formal studies done yet. As of November 2011, there have been no reports of death associated with the drug. The toxicity of AM-2201 is still a matter of debate, and there is no certainty of long-term side effects.
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
for the cannabinoid receptor
Cannabinoid receptor
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains...
CB1, with a Ki
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 1.0nM at CB1 and 2.6nM at CB2
Cannabinoid receptor 2 (macrophage)
Cannabinoid receptor 2 , also known as CB2 or CNR2, is a G protein-coupled receptor from the cannabinoid receptor family, which in humans is encoded by the CNR2 gene...
. Reputed recreational use of AM-2201 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act
Controlled Substances Act
The Controlled Substances Act was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970. The CSA is the federal U.S. drug policy under which the manufacture, importation, possession, use and distribution of certain...
, aiming to add a number of synthetic drugs into Schedule I. There have been anecdotal reports of individuals experiencing panic attacks
Panic attack
Panic attacks are periods of intense fear or apprehension that are of sudden onset and of relatively brief duration. Panic attacks usually begin abruptly, reach a peak within 10 minutes, and subside over the next several hours...
and vomiting, at doses as small as 2 milligrams. As the dosage is much smaller than most other synthetic cannabinoids, users may accidentally dose too much. Convulsions have been reported at doses exceeding 10 milligrams. Caution should be taken if using this substance as it is active at doses as small as 500 µg (micrograms), and has a very steep dose-response curve. Tolerance builds up quickly to the effects, and psychological dependence is possible, although there have been no formal studies done yet. As of November 2011, there have been no reports of death associated with the drug. The toxicity of AM-2201 is still a matter of debate, and there is no certainty of long-term side effects.