The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. At least 20 AKAPs have been cloned. There are at least 50 members. Often named after their MW.

• AKAP1
  AKAP1
  A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.-Interactions:AKAP1 has been shown to interact with MYCBP, C3orf15, PRKAR1A, PRKAR2A and PRKAR1B.-Further reading:...
  
  
• AKAP2
  AKAP2
  A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene.-Further reading:...
  
  
• AKAP3
  AKAP3
  A-kinase anchor protein 3 is an enzyme that in humans is encoded by the AKAP3 gene.-Interactions:AKAP3 has been shown to interact with GNA13, AKAP4 and PRKAR2A.-Further reading:...
  
  
• AKAP4
  AKAP4
  A-kinase anchor protein 4 is an enzyme that in humans is encoded by the AKAP4 gene.-Interactions:AKAP4 has been shown to interact with PRKAR1A and AKAP3.-Further reading:...
  
  
• AKAP5
  AKAP5
  A-kinase anchor protein 5 is an enzyme that in humans is encoded by the AKAP5 gene.-Interactions:AKAP5 has been shown to interact with Calcineurin and GABRB3.-Further reading:...
  
  
• AKAP6
  AKAP6
  A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.-Interactions:AKAP6 has been shown to interact with Ryanodine receptor 2 and PDE4A.-Further reading:...
  
  
• AKAP7
  AKAP7
  A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.-Further reading:...
  
  
• AKAP8
  AKAP8
  A-kinase anchor protein 8 is an enzyme that in humans is encoded by the AKAP8 gene.-Interactions:AKAP8 has been shown to interact with DDX5, AMY1A, MCM2, Cyclin D3 and PRKAR2A.-Further reading:...
  
  
• AKAP9
  AKAP9
  A-kinase anchor protein 9 is an enzyme that in humans is encoded by the AKAP9 gene.-Interactions:AKAP9 has been shown to interact with Calmodulin 1, FNBP1, CALM2, Protein kinase N1, TRIP10, KvLQT1 and PRKAR2A.-Further reading:...
  
  
• AKAP10
  AKAP10
  A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.-Interactions:AKAP10 has been shown to interact with PDZK1 and PRKAR1A.-Further reading:...
  
  
• AKAP11
  AKAP11
  A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.-Interactions:AKAP11 has been shown to interact with PPP1CA, GSK3B, PRKAR2A and PRKAR2B.-Further reading:...
  
  
• AKAP12
  AKAP12
  A-kinase anchor protein 12 is an enzyme that in humans is encoded by the AKAP12 gene.-Interactions:AKAP12 has been shown to interact with Beta-2 adrenergic receptor.-Further reading:...
  
  
• AKAP13
  AKAP13
  A-kinase anchor protein 13 is an enzyme that in humans is encoded by the AKAP13 gene.-Interactions:AKAP13 has been shown to interact with Estrogen receptor alpha, CTNNAL1 and PRKAR2A.-Further reading:...
  
  

Function

AKAPs act as targeting devices that assemble signaling elements on a scaffold that itself targets to microdomains in cells. This allows specific targeting of substrates to be regulated by phosphorylation (by PKA) and dephosphorylation (by phosphatases).
PKA binds directly to an AKAP by its regulatory subunits (RIα, RIIα, RIβ, RIIβ) to an amphipathic α-helix to which all AKAPs have in common.
The AKAPs also bind other components including; phosphodiesterases (PDEs) which break down cAMP, phosphatases which dephosphorylate downstream PKA targets and also other kinases (PKC and MAPK).
Some AKAPs are able to bind both regulatory subunits (RI & RII) of PKA and are dual-specific AKAPs (D-AKAP1 and D-AKAP2)