ADAM is a family of peptidase proteins. It is also known as the adamalysin family or MDC family(metalloproteinase-like, Disintegrin-like, cysteine rich). ADAMs are classified as sheddase

Sheddase

Sheddases are membrane-bound enzymes that cleave extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface...

s because they cut off or shed extracellular portions of transmembrane proteins. For example, ADAM10 can cut off part of the HER2 receptor, activating it. Therapeutic ADAM inhibitors can potentiate anti-cancer therapy.

It is categorized under .

Family members are:

• ADAM2
  ADAM2
  Disintegrin and metalloproteinase domain-containing protein 2 is an enzyme that in humans is encoded by the ADAM2 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAM7
  ADAM7
  ADAM7 is a member of the ADAM gene family. It is important for the maturation of sperm cells in mammals.-External links:* The MEROPS online database for peptidases and their inhibitors: *...
  
  
• ADAM8
  ADAM8
  A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.-External Links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAM9
  ADAM9
  Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.-Interactions:ADAM9 has been shown to interact with MAD2L2, SNX9 and SH3GL2.-External links:...
  
  
• ADAM10
  ADAM10
  Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene.- Function :...
  
  
• ADAM11
  ADAM11
  Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAM12
  ADAM12
  For the television show, see Adam 12Disintegrin and metalloproteinase domain-containing protein 12 is an enzyme that in humans is encoded by the ADAM12 gene.-Interactions:...
  
  
• ADAM15
  ADAM15
  Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene.-Interactions:ADAM15 has been shown to interact with Grb2, HCK, SNX9, Lck and SH3GL2.-External links:...
  
  
• ADAM17
  ADAM17
  ADAM metallopeptidase domain 17 , also called TACE , is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.- Chemical characteristics :...
  
  
• ADAM18
  ADAM18
  Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
   (=ADAM27)
• ADAM19
  ADAM19
  ADAM19 , is a human gene.-Further reading:...
  
  
• ADAM20
• ADAM21 (=ADAM31)
• ADAM22
  ADAM22
  Disintegrin and metalloproteinase domain-containing protein 22 also known as ADAM22 is an enzyme that in humans is encoded by the ADAM22 gene.- Function :...
  
  
• ADAM23
  ADAM23
  Disintegrin and metalloproteinase domain-containing protein 23 is an enzyme that in humans is encoded by the ADAM23 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAM28
  ADAM28
  Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
  
• ADAM29
• ADAM30
• ADAM33
  ADAM33
  Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.-External links:* The MEROPS online database for peptidases and their inhibitors:...
  
  

See also

• ADAMTS
  ADAMTS
  ADAMTS is a family of peptidases. 19 members of this family have been identified in humans. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan...
  
   (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) family
• Ectodomain shedding

External links

• http://www.healthvalue.net/sheddase.html