ACAT2
Encyclopedia
Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme
that in human
s is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene
that is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB.
Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase
enzyme.
and human. These genes are encoded on opposite strands of DNA
, as well as in opposite transcriptional orientation.
, and it encodes cytosolic acetoacetyl-CoA thiolase.
In a study done on rats, it was found that rats fed a fat-enriched diet whose ACAT2 gene were deleted were protected from dietary fat-induced atherosclerosis
. LDL concentration, CE composition, and particle size were affected in ways that reduced atherogenesis in comparison to other rats whose ACAT2 gene were not modified.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in human
Human
Humans are the only living species in the Homo genus...
s is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
that is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB.
Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase
Acetyl-CoA C-acetyltransferase
In enzymology, an acetyl-CoA C-acetyltransferase is an enzyme that catalyzes the chemical reactionHence, this enzyme has one substrate, acetyl-CoA, and two products, CoA and acetoacetyl-CoA....
enzyme.
Gene
This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouseMouse
A mouse is a small mammal belonging to the order of rodents. The best known mouse species is the common house mouse . It is also a popular pet. In some places, certain kinds of field mice are also common. This rodent is eaten by large birds such as hawks and eagles...
and human. These genes are encoded on opposite strands of DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
, as well as in opposite transcriptional orientation.
Function
The product of this gene is an enzyme involved in lipid metabolismLipid metabolism
Lipid metabolism refers to the processes that involve the intercourse and degradation of lipids.The types of lipids involved include:* Bile salts* Cholesterols* Eicosanoids* Glycolipids* Ketone bodies* Fatty acids - see also fatty acid metabolism...
, and it encodes cytosolic acetoacetyl-CoA thiolase.
In a study done on rats, it was found that rats fed a fat-enriched diet whose ACAT2 gene were deleted were protected from dietary fat-induced atherosclerosis
Atherosclerosis
Atherosclerosis is a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol...
. LDL concentration, CE composition, and particle size were affected in ways that reduced atherogenesis in comparison to other rats whose ACAT2 gene were not modified.