5-Formiminotetrahydrofolate
Encyclopedia
5-Formiminotetrahydrofolate is an intermediate in the catabolism
of histidine
. It is produced by glutamate formimidoyltransferase
and then converted into 5,10-methenyltetrahydrofolate
by formiminotransferase cyclodeaminase
.
Catabolism
Catabolism is the set of metabolic pathways that break down molecules into smaller units and release energy. In catabolism, large molecules such as polysaccharides, lipids, nucleic acids and proteins are broken down into smaller units such as monosaccharides, fatty acids, nucleotides, and amino...
of histidine
Histidine
Histidine Histidine, an essential amino acid, has a positively charged imidazole functional group. It is one of the 22 proteinogenic amino acids. Its codons are CAU and CAC. Histidine was first isolated by German physician Albrecht Kossel in 1896. Histidine is an essential amino acid in humans...
. It is produced by glutamate formimidoyltransferase
Glutamate formimidoyltransferase
In molecular biology, Glutamate formimidoyltransferase is a methyltransferase enzyme which uses tetrahydrofolate as part of histidine catabolism...
and then converted into 5,10-methenyltetrahydrofolate
5,10-Methenyltetrahydrofolate
5,10-Methenyltetrahydrofolate is a form of tetrahydrofolate that is an intermediate in metabolism. 5,10-CH=THF is a coenzyme that accepts and donates methenyl groups....
by formiminotransferase cyclodeaminase
Formiminotransferase cyclodeaminase
Formiminotransferase cyclodeaminase is an enzyme that catalyzes the conversion of formiminoglutamate and tetrahydrofolate into formiminotetrahydrofolate and glutamate....
.