Noun

1. Nuclear weapon.

   "I can buy nukes on the black market for $40 million each" - John Travolta in the movie Swordfish.

2. Something that negates - especially on a catastrophic scale. Destruction.
3. A microwave oven

   "Just put it in the nuke for two minutes and then eat it."

4. Nuclear electrical power generation station.

Verb

1. To use a nuclear weapon on a target.

   First they nuked Hiroshima, then Nagasaki.

2. To cook food or beverages in a microwave oven.

   I'll nuke some pizza for dinner.

3. To completely destroy.

   To try to hide his posting history on Usenet, he had his posts nuked from the Google archives. (see also expunge)