Why Zebras Don't Get Ulcers
Encyclopedia
Why Zebras Don't Get Ulcers is a 1994 (2ed 1998, 3ed 2004) book by Stanford University
Stanford University
The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private research university on an campus located near Palo Alto, California. It is situated in the northwestern Santa Clara Valley on the San Francisco Peninsula, approximately northwest of San...

 biologist Robert M. Sapolsky
Robert Sapolsky
Robert Maurice Sapolsky is an American scientist and author. He is currently Professor of Biological Sciences, and Professor of Neurology and Neurological Sciences and, by courtesy, Neurosurgery, at Stanford University. In addition, he is a Research Associate at the National Museums of...

. The book proclaims itself as a "Guide to Stress, Stress-Related Diseases, and Coping" on the front cover of its third and most recent edition. The name stems from Sapolsky's insistence that wild animals are less susceptible than humans to stress-related disorders such as ulcers
Peptic ulcer
A peptic ulcer, also known as PUD or peptic ulcer disease, is the most common ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. It is defined as mucosal erosions equal to or greater than 0.5 cm...

, hypertension
Hypertension
Hypertension or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated. What that means is that the heart is having to work harder than it should to pump the blood around the body. Blood pressure involves two measurements, systolic and...

, decreased neurogenesis
Neurogenesis
Neurogenesis is the process by which neurons are generated from neural stem and progenitor cells. Most active during pre-natal development, neurogenesis is responsible for populating the growing brain with neurons. Recently neurogenesis was shown to continue in several small parts of the brain of...

 and increased hippocampal neuronal atrophy.

Sapolsky focuses on the effects of glucocorticoids on the human body, stating that such hormones may be useful to animals in the wild escaping their predators, but the effects on humans, when secreted at high quantities or over long periods of time, are much less desired. Sapolsky relates the history of endocrinology, how the field reacted at times of discovery, and how it has changed through the years. While most of the book focuses on the biological machinery of the body, the last chapter of the book focuses on self-help.

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