"What U Gon' Do" is a single by Lil Jon & the Eastside Boyz from their album Crunk Juice

Crunk Juice (album)

Crunk Juice is the fifth studio album by American recording artists Lil Jon & the East Side Boyz, released in November 16, 2004, on TVT/BME...

and features Lil Scrappy

Lil Scrappy

Darryl Kevin Richardson II , better known by his stage name Lil Scrappy, is an American rapper.Richards was discovered by producer and performer Lil Jon while performing at a bar, when a fight broke out during his set in his hometown of Atlanta, Georgia...

. It is one of the best known songs that Lil' Jon & The Eastside Boyz recorded together. It also launched Lil' Scrappy's career worldwide.

The track reached #22 on the Billboard Hot 100

Billboard Hot 100

The Billboard Hot 100 is the United States music industry standard singles popularity chart issued weekly by Billboard magazine. Chart rankings are based on radio play and sales; the tracking-week for sales begins on Monday and ends on Sunday, while the radio play tracking-week runs from Wednesday...

, #8 on the Hot Rap Tracks

Hot Rap Tracks

Rap Songs is a chart released weekly by Billboard in the United States. It lists the 25 most popular hip-hop/rap songs, calculated weekly by airplay on rhythmic and urban radio stations and sales in hip hop-focused or exclusive markets. From 1989 through 2001, it was based on how much the single...

 chart, and #13 on the Hot R&B/Hip-Hop Singles & Tracks chart.

Two remixes to the song was an addition to the Crunk Juice in the Remix CD. A Jamaican remix featuring Elephant Man and Lady Saw

Lady Saw

Lady Saw is a Jamaican reggae singer, known as the queen of dancehall.-Biography:...

 and a Latino remix featuring Pitbull

Pitbull (rapper)

Armando Christian Pérez , better known by his stage name Pitbull, is an American rapper, singer-songwriter and record producer. His first recorded performance was from the Lil Jon album Kings of Crunk in 2002, after which he released his debut album in 2004 titled M.I.A.M.I. under TVT Records...

 and Daddy Yankee

Daddy Yankee

Ramón Luis Ayala Rodríguez , known artistically as Daddy Yankee, is a Latin Grammy Award winning Puerto Rican Reggaeton recording artist. Ayala was born in Río Piedras, the largest district of San Juan, where he became interested in music at a young age. In his youth he was interested in baseball,...

. The Latino remix became the official remix.

The song appeared in a season one episode of The Andy Milonakis Show

The Andy Milonakis Show

The Andy Milonakis Show is an American sketch comedy television show starring Andy Milonakis, which aired on MTV2, the first season having aired on MTV...

when Lil Jon guest starred.