In Oklahoma, U.S. Highway 62 runs diagonally across the state, from the Texas

Texas

Texas is the second largest U.S. state by both area and population, and the largest state by area in the contiguous United States.The name, based on the Caddo word "Tejas" meaning "friends" or "allies", was applied by the Spanish to the Caddo themselves and to the region of their settlement in...

 state line in far southwestern Oklahoma to the Arkansas

Arkansas

Arkansas is a state located in the southern region of the United States. Its name is an Algonquian name of the Quapaw Indians. Arkansas shares borders with six states , and its eastern border is largely defined by the Mississippi River...

 state line near Fayetteville

Fayetteville, Arkansas

Fayetteville is the county seat of Washington County, and the third largest city in Arkansas. The city is centrally located within the county and is home to the University of Arkansas. Fayetteville is also deep in the Boston Mountains, a subset of The Ozarks...

. US-62 spends a total of 402.48 miles (647.7 km) in the Sooner State. The highway passes through fifteen of Oklahoma's counties. Along the way the route serves two of Oklahoma's largest cities, Lawton

Lawton, Oklahoma

The city of Lawton is the county seat of Comanche County, in the U.S. state of Oklahoma. Located in the southwestern region of Oklahoma approximately southwest of Oklahoma City, it is the principal city of the Lawton Oklahoma Metropolitan Statistical Area...

 and Oklahoma City

Oklahoma City, Oklahoma

Oklahoma City is the capital and the largest city in the state of Oklahoma. The county seat of Oklahoma County, the city ranks 31st among United States cities in population. The city's population, from the 2010 census, was 579,999, with a metro-area population of 1,252,987 . In 2010, the Oklahoma...

, as well as many regionally important cities, like Altus

Altus, Oklahoma

Altus is a city in Jackson County, Oklahoma, United States. The population was 19,813 at the 2010 census. It is the county seat of Jackson County....

, Chickasha

Chickasha, Oklahoma

Chickasha is a city in and the county seat, business and employment center of Grady County, Oklahoma, United States. The population was 15,850 at the 2000 census. Chickasha is home to the University of Science and Arts of Oklahoma and hosts an annual Festival of Light celebration located at...

, Muskogee

Muskogee, Oklahoma

Muskogee is a city in Muskogee County, Oklahoma, United States. It is the county seat of Muskogee County, and home to Bacone College. The population was 38,310 at the 2000 census, making it the eleventh-largest city in Oklahoma....

, and Tahlequah

Tahlequah, Oklahoma

Tahlequah is a city in Cherokee County, Oklahoma, United States located at the foothills of the Ozark Mountains. It was founded as a capital of the original Cherokee Nation in 1838 to welcome those Cherokee forced west on the Trail of Tears. The city's population was 15,753 at the 2010 census. It...

.