U.S. Route 61
U.S. Route 61 is the official designation for a United States highway that runs 1400 miles (2,253.1 km) from New Orleans, Louisiana
Louisiana is a state located in the southern region of the United States of America. Its capital is Baton Rouge and largest city is New Orleans. Louisiana is the only state in the U.S. with political subdivisions termed parishes, which are local governments equivalent to counties...

, to the city of Wyoming, Minnesota
Wyoming, Minnesota
As of the census of 2000, there were 3,048 people, 1,023 households, and 848 families residing in the city. The population density was 1,069.8 people per square mile . There were 1,055 housing units at an average density of 370.3 per square mile...

. The highway generally follows the course of the Mississippi River
Mississippi River
The Mississippi River is the largest river system in North America. Flowing entirely in the United States, this river rises in western Minnesota and meanders slowly southwards for to the Mississippi River Delta at the Gulf of Mexico. With its many tributaries, the Mississippi's watershed drains...

, and is designated the Great River Road
Great River Road
The Great River Road is a collection of state, provincial, federal, and local roads which follow the course of the Mississippi River through ten states of the United States...

 for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota is at an intersection with Interstate 35
Interstate 35
Interstate 35 is a north–south Interstate Highway in the central United States. I-35 stretches from Laredo, Texas, on the U.S.-Mexico border to Duluth, Minnesota, at Minnesota Highway 61 and 26th Avenue East. Many interstates used to have splits or spurs indicated with suffixed letters , but I-35...

. Prior to 1991, the highway extended north on what is now MN 61 through Duluth
Duluth, Minnesota
Duluth is a port city in the U.S. state of Minnesota and is the county seat of Saint Louis County. The fourth largest city in Minnesota, Duluth had a total population of 86,265 in the 2010 census. Duluth is also the second largest city that is located on Lake Superior after Thunder Bay, Ontario,...

 to the United States-Canada border near Grand Portage
Grand Portage, Minnesota
Grand Portage is an unorganized territory in Cook County, Minnesota, on Lake Superior, at the northeast corner of the state near the border with northwestern Ontario. The population was 557 at the 2000 census...