Schöpf–Schulz–Passarge syndrome (also known as "Eyelid cysts, palmoplantar keratoderma, hypodontia, and hypotrichosis") is an autosomal recessive condition with diffuse symmetric palmoplantar keratoderma

Palmoplantar keratoderma

Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the palms and soleAutosomal recessive and dominant, X-linked, and acquired forms have all been described.There are also acquired forms of the condition....

, with the palmoplantar keratoderma and fragility of the nails beginning around age 12.

It was characterized in 1971.

It has been associated with WNT10A

WNT10A

Wnt-10a is a protein that in humans is encoded by the WNT10A gene.- Function :The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell...

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