Mr. and Mrs. Spider-Man was a short comic strip series published in the pages of Amazing Spider-Man Family

Spider-Man Family

Spider-Man Family is a comic book series published by Marvel Comics. It began as a series of one-shots written and penciled by various writers and artists before becoming a bi-monthly ongoing series with the first issue cover-dated February 2007. Its initial writer was Sean McKeever...

, in August 2008. It was written by Tom DeFalco

Tom DeFalco

Tom DeFalco is an American comics writer and editor, well known for his association with Marvel Comics and in particular for his work with Spider-Man.-Career:...

, and illustrated by Ron Frenz

Ron Frenz

Ronald Wade Frenz is an American comic book artist known for his work for Marvel Comics. He is well-known for his 1980s work on Amazing Spider-Man, and more recently, for his work on Spider-Girl...

 and several other artists.

The series took place in the MC2 universe, and bridges the gap between the final issues of DeFalco's run on The Amazing Spider-Man

The Amazing Spider-Man

The Amazing Spider-Man is an American comic book series published by Marvel Comics, featuring the adventures of the fictional superhero Spider-Man. Being the mainstream continuity of the franchise, it began publication in 1963 as a monthly periodical and was published continuously until it was...

and his future canon in Spider-Girl

Spider-Girl

Spider-Girl is a superheroine in Marvel Comics' MC2 universe. The character was created by Tom DeFalco and Ron Frenz as the teenage daughter of Spider-Man and Mary Jane Watson, and first appeared in What If #105...

, taking place shortly after the renegade clone Kaine

Kaine

Kaine is a fictional character, a Marvel Comics supervillain and antihero who serves as both an ally and an enemy of Spider-Man. He first appeared in Web of Spider-Man #119, and is the Jackal's first failed attempt at cloning Peter Parker...

 rescued an infant Mayday Parker from the clutches of Norman Osborn's agents and returned her safely to her parents Peter

Spider-Man

Spider-Man is a fictional Marvel Comics superhero. The character was created by writer-editor Stan Lee and writer-artist Steve Ditko. He first appeared in Amazing Fantasy #15...

 and Mary Jane

Mary Jane Watson

Mary Jane Watson, often shortened to MJ, is a fictional supporting character appearing, originally, in Marvel comic books and, later, in multiple spin-offs and dramatizations of the Spider-Man titles as the best friend, love interest, and one-time wife of Peter Parker, the alter ego of Spider-Man...

. Peter continues his career as Spider-Man and begins to cope with the additional headaches of raising an infant daughter with his wife.

According to DeFalco, the events of The Final Chapter

The Final Chapter (comics)

"The Final Chapter" was a four-part storyline from Marvel Comics published in 1999. The storyline immediately followed events from "The Gathering of Five" arc, and the opening chapter deals with the five summoned by Osborn acquiring their "gifts"...

take place two years after this series. Mayday is six months old when the series begins, and is two when Peter loses his leg in a final battle with the Green Goblin, ending his career as Spider-Man.

The strip was originally intended to run in the closing issue of the "Spider-Man Family" volume, but had since been held back to launch within the rebranded title. A podcast interview with DeFalco in November 2008 confirmed that, due to Spider-Girl becoming an integral part of Amazing Spider-Man Family, Mr and Mrs. Spider-Man would become a casualty and will be concluded. Only four storylines were written. The strips were later collected in a trade paperback of The Spectacular Spider-Girl