Hand-Schüller-Christian disease
Encyclopedia
Hand-Schüller-Christian disease is associated with multifocal Langerhans cell histiocytosis
.
It is associated with a triad of exophthalmos
, lytic bone lesions (often in the skull), and diabetes insipidus
(from pituitary stalk infiltration).
It is named for Alfred Hand, Artur Schüller, and Henry Asbury Christian.
Langerhans cell histiocytosis
Langerhans cell Histiocytosis is a rare disease involving clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes...
.
It is associated with a triad of exophthalmos
Exophthalmos
Exophthalmos is a bulging of the eye anteriorly out of the orbit. Exophthalmos can be either bilateral or unilateral . Measurement of the degree of exophthalmos is performed using an exophthalmometer...
, lytic bone lesions (often in the skull), and diabetes insipidus
Diabetes insipidus
Diabetes insipidus is a condition characterized by excessive thirst and excretion of large amounts of severely diluted urine, with reduction of fluid intake having no effect on the concentration of the urine. There are several different types of DI, each with a different cause...
(from pituitary stalk infiltration).
It is named for Alfred Hand, Artur Schüller, and Henry Asbury Christian.