Elimination rate constant
Encyclopedia
Elimination rate constant is a value used in pharmacokinetics
Pharmacokinetics
Pharmacokinetics, sometimes abbreviated as PK, is a branch of pharmacology dedicated to the determination of the fate of substances administered externally to a living organism...

 to calculate the rate at which drugs are removed from the system.

It is often abbreviated K or Ke. It is equivalent to the fraction of a substance that is removed per unit time measured at any particular instant and has units of T
Time
Time is a part of the measuring system used to sequence events, to compare the durations of events and the intervals between them, and to quantify rates of change such as the motions of objects....

-1 This can be expressed mathematically as , where is the concentration of drug in the system at a given point in time, is an infinitely small change in time, and is the concentration of drug in the system after the infinitely small change in time.

It is useful in calculating the change in plasma concentration after the administration of a single dose of drug:

  • Ct is concentration after time t
  • C0 is the initial concentration (t=0)
  • k is the elimination rate constant
    Elimination rate constant
    Elimination rate constant is a value used in pharmacokinetics to calculate the rate at which drugs are removed from the system.It is often abbreviated K or Ke...

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