C. Robin Ganellin
Encyclopedia
Charon Robin Ganellin is a British born medicinal chemist. He has contributed much to the field of drug discovery and development. His most outstanding achievement was the discovery of cimetidine
Cimetidine
Cimetidine INN is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. It is largely used in the treatment of heartburn and peptic ulcers. It is marketed by GlaxoSmithKline under the trade name Tagamet...

, a drug used to combat stomach ulcers, when he was working at Smith Kline and French. He has received many awards and much recognition for his scientific pursuits over the years. He now lives near London and is a professor at University College London.

Early life

Born in East London
London
London is the capital city of :England and the :United Kingdom, the largest metropolitan area in the United Kingdom, and the largest urban zone in the European Union by most measures. Located on the River Thames, London has been a major settlement for two millennia, its history going back to its...

 on 1934 January 25, Charon Robin Ganellin knew from an early age that his calling was chemistry. During his studies at Harrow County School for Boys, he developed a strong aptitude for science and maths, but his performance in language and history was lacking. Although he enjoyed biology and natural history above his other subjects, he was influenced to pursue a career in chemistry. Because his father and his maternal uncle were chemists, he recognised that chemists could make a living. Uncertain if a career in biology was possible, he decided to become a chemist. He began his formal studies at Queen Mary College
Queen Mary, University of London
Queen Mary, University of London is a public research university located in London, United Kingdom and a constituent college of the federal University of London...

 in London where he received his first degree, a bachelor of science in chemistry. He continued his studies at Queen Mary College
Queen Mary, University of London
Queen Mary, University of London is a public research university located in London, United Kingdom and a constituent college of the federal University of London...

, researching tropylium chemistry with Michael J.S. Dewar where he discovered how to isolate the tropylium cation from cyclooctatetraene. For this research, he was awarded his Ph.D. in organic chemistry in 1958 at the age of twenty-four.

Scientific Work

In 1958, shortly after his Ph.D. studies at Queen Mary College, Ganellin joined Smith Kline and French Laboratories in the UK where he began research in medicinal chemistry. Two years after starting at SK&F, he went to the Massachusetts Institute of Technology
Massachusetts Institute of Technology
The Massachusetts Institute of Technology is a private research university located in Cambridge, Massachusetts. MIT has five schools and one college, containing a total of 32 academic departments, with a strong emphasis on scientific and technological education and research.Founded in 1861 in...

 where he performed his postdoctoral work with Arthur C. Cope. At MIT he devised the first direct optical resolution of a chiral olefin using platinum complex chemistry. After a year at MIT, he returned to the United Kingdom to resume his work at SK&F. In 1966 he headed a landmark research team at SK&F, collaborating with Sir James Black researching histamine H2-receptor antagonists. This research eventually led to the discovery of cimetidine
Cimetidine
Cimetidine INN is a histamine H2-receptor antagonist that inhibits the production of acid in the stomach. It is largely used in the treatment of heartburn and peptic ulcers. It is marketed by GlaxoSmithKline under the trade name Tagamet...

, also known by its trademark name Tagamet which is currently produced by GlaxoSmith Kline.

Cimetidine was a revolutionary drug at the time of its creation. Peptic ulcers, or stomach ulcers, used to be a very serious medical condition. Stomach ulcers were very difficult to treat and caused a great deal of pain. If left untreated, they could even be life threatening. In some cases, surgery was required to remove the ulcer. Because of these factors, cimetidine was an incredibly popular drug after it was approved for prescription. Cimetidine first entered the market in the United Kingdom in 1976, and was received extremely well. Cimetidine quickly garnered over one billion dollars in annual sales, making it the first blockbuster drug, and it is currently listed by the World Health Organization as one of the most essential drugs.

Ganellin’s contribution to this research was integral to its success. His adeptness at physical organic chemistry enabled him to understand the individual H2-receptor antagonist drugs they developed. Initially, the team developed burimamide
Burimamide
Burimamide is an antagonist at the H2 and H3 histamine receptors. It is largely inactive as an H2 antagonist at physiological pH, but its H3 affinity is 100x higher. It is a thiourea derivative....

 as a potential H2-receptor antagonist for medicinal use. However, it was soon realized that burimamide was not an appropriate oral medicine. They quickly identified a similar drug, metiamide
Metiamide
Metiamide is a histamine H2-receptor antagonist developed from another H2 antagonist, burimamide. It was an intermediate compound in the development of the successful anti-ulcer drug cimetidine .-Development of metiamide from burimamide:...

, which appeared to have clinical potential. However, metiamide also had a shortcoming – its safety was uncertain. The end result of their trials was cimetidine, an H2-receptor antagonist superior to both burimamide and metiamide. The precursor drugs which marked the progress of their research are termed prototypes. These prototype drugs helped them understand the mechanisms that described how the drugs function. Ganellin’s input was vital to the progression of their research along the sequence of prototypes to final product.

Although Ganellin’s contribution to the discovery of cimetidine was immeasurable, he was not alone. He collaborated with many other scientists at SmithKline and French, including fellow medicinal chemist Graham J. Durant. Durant was able to provide his expertise on guanidine
Guanidine
Guanidine is a crystalline compound of strong alkalinity formed by the oxidation of guanine. It is used in the manufacture of plastics and explosives. It is found in urine as a normal product of protein metabolism. The molecule was first synthesized in 1861 by the oxidative degradation of an...

 chemistry to further the progress of the research. Sir James Whyte Black, a biologist from Scotland, was also instrumental in their research. He identified the role of the H2-receptor in the production of stomach acid. This discovery was crucial to their research, providing the impetus to search for a suitable H2-receptor antagonist to affect production of stomach acid. John C. Emmett, another medicinal chemist, is also credited as a co-discoverer of cimetidine. In addition to these key players, many others contributed to the research, such as William Duncan, the director of research at SK&F, as well as Michael Parsons, whose pharmacological experience was greatly beneficial.

Later life

Ganellin’s collaborators influenced him and imparted in him knowledge and experience which has remained with him throughout the decades. Ganellin once said that the one achievement that gave him the “most professional pride” was his discovery of cimetidine. This period of his life has defined his scientific career, while also providing him with inspiration to continue his research in medicinal chemistry. Although Ganellin considers cimetidine his greatest achievement, he has never wavered in his devotion to scientific research. After his work on cimetidine was complete, he was given the position of vice-president for research at SK&F’s Welwyn
Welwyn
Welwyn is a village and civil parish in Hertfordshire, England. The parish also includes the villages of Digswell and Oaklands. It is sometimes called Old Welwyn to distinguish it from the newer settlement of Welwyn Garden City, about a mile to the south.-History:Situated in the valley of the...

 facility. After his considerable tenure at SmithKline & French came to an end in 1986, Ganellin has continued to remain active in the affairs of medicinal chemistry. Shortly before leaving, he was awarded his D.Sc. from London University for his research and publications on histaminergic drugs and elected as a Fellow of the Royal Society (the UK’s National Academy of Science). In 1986, he was appointed as the SmithKline & French Chair of Medicinal Chemistry at University College London where he began a lengthy career in academia.

Awards and achievements

Since then, Robin Ganellin has authored or co-authored over 260 scientific papers and is listed as inventor or co-inventor on over 160 U.S. patents. He has served as the president of the IUPAC medicinal chemistry section, and he is currently the chair of the subcommittee on medicinal chemistry and drug development. He has won many awards and commendations over the years, both for his work on cimetidine and his research in other areas of medicinal chemistry. He has received awards in medicinal chemistry from many organizations, such as the Royal Society of Chemistry
Royal Society of Chemistry
The Royal Society of Chemistry is a learned society in the United Kingdom with the goal of "advancing the chemical sciences." It was formed in 1980 from the merger of the Chemical Society, the Royal Institute of Chemistry, the Faraday Society and the Society for Analytical Chemistry with a new...

, the American Chemical Society
American Chemical Society
The American Chemical Society is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 161,000 members at all degree-levels and in all fields of chemistry, chemical...

, the Society of Chemical Industry
Society of Chemical Industry
The Society of Chemical Industry is a learned society set up in 1881 "to further the application of chemistry and related sciences for the public benefit". Its purpose is "Promoting the commercial application of science for the benefit of society". Its first president was Henry Enfield Roscoe and...

, the Society for Drug Research, the European Federation for Medicinal Chemistry and the Medicinal Chemistry Division of the Italian Chemical Society. He was also inducted into the US National Inventors Hall of Fame
National Inventors Hall of Fame
The National Inventors Hall of Fame is a not-for-profit organization dedicated to recognizing, honoring and encouraging invention and creativity through the administration of its programs. The Hall of Fame honors the men and women responsible for the great technological advances that make human,...

in 1990 for his work on cimetidine. Ganellin currently serves as the Emeritus Professor of Medicinal Chemistry, although he is now partially retired.
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