Protein 4.1, also known as Beatty's Protein, is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 associated with the cytoskeleton

Cytoskeleton

The cytoskeleton is a cellular "scaffolding" or "skeleton" contained within a cell's cytoplasm and is made out of protein. The cytoskeleton is present in all cells; it was once thought to be unique to eukaryotes, but recent research has identified the prokaryotic cytoskeleton...

 that in humans is encoded by the EPB41 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Protein 4.1 (80 kD) interacts with spectrin and short actin filaments to form the erythrocyte membrane skeleton. Mutations of spectrin and protein 4.1 are associated with elliptocytosis or spherocytosis and anemia of varying severity.

Interactions

Band 4.1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1

Nuclear mitotic apparatus protein 1 is a protein that in humans is encoded by the NUMA1 gene.-Interactions:Nuclear mitotic apparatus protein 1 has been shown to interact with PIM1, Band 4.1, GPSM2 and EPB41L1.-Further reading:...

, Tight junction protein 2

Tight junction protein 2

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.-Interactions:Tight junction protein 2 has been shown to interact with Tight junction protein 1, Band 4.1 and Occludin.-Further reading:...

, EIF3G

EIF3G

Eukaryotic translation initiation factor 3 subunit G is a protein that in humans is encoded by the EIF3G gene.-Interactions:EIF3G has been shown to interact with Band 4.1, EIF3C and EIF3A.-Further reading:...

 and CENPJ

CENPJ

Centromere protein J is a protein that in humans is encoded by the CENPJ gene. It is also known as centrosomal P4.1-associated protein .-Further reading:...

.

Further reading

External links