You are given a series of food digests to analyse by ICP-MS. The concentrations of several trace elements(Mn,Cu,Co,As,Cd,Hg and Pb) are the matrix elements (Na,Ca,Mg and K) are to be determined within a single run.The former may be at slightly below the detection limit whereas latter should be at the levels near the upper end of linear dynamic range of the instrument.
a) Propose a flow injection manifold that would allow the determination of all these analytes by ICP-MS. justify.
b) Which m/z should be monitored for each analyte?
c) Could the analysis be done by ICP-MS equipped with quadrupole (without collision cell)or time of flight mass spectrometer ?If not, which mass resolution would be required?